Family

Ubinuclein-1 (IPR026936)

Short name: Ubinuclein-1

Family relationships

None.

Description

Ubinuclein-1 (UBN1) is part of the histone chaperone complex HIRA/UBN1/CABIN1/ASF1a that preferentially deposits the histone variant H3.3 into chromatin and is implicated in diverse chromatin regulatory events from gene activation to heterochromatinisation [PMID: 21807893, PMID: 22401310].

Ubinuclein-1 interacts with HIRA and is involved in the formation of senescence-associated heterochromatin foci (SAHF). SAHF are domains of specialised chromatin found in senescent cells that repress expression of proliferation-promoting genes [PMID: 19029251].

GO terms

Biological Process

GO:0006325 chromatin organization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER