Myelin gene regulatory factor (IPR026933)

Short name: MRF

Overlapping homologous superfamilies


Family relationships



This entry represents metazoan myelin gene regulatory factor (MRF). MRF is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination [PMID: 19596243]. It is also required for the maintenance of expression of myelin genes and the mature oligodendrocytes identity in the adult CNS [PMID: 22956843]. A Caenorhabditis elegans orthologue, pqn-47, may function as a regulator of molting [PMID: 21989027], while a Dictyostelium orthologue has been described to regulate prestalk differentiation [PMID: 22811266].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.