Alpha-actinin 1 (IPR026921)

Short name: Alpha-actinin_1

Overlapping homologous superfamilies


Family relationships



Alpha-actinin bundles actin filaments and cross-links F-actin to anchor actin to a variety of intracellular-structures [PMID: 6746725, PMID: 21241830]. Four isoforms of human alpha-actinin have been identified: nonmuscle actinin-1, muscle actinin-2, muscle actinin-3 and nonmuscle actinin-4 [PMID: 9508771]. Alpha-actinin 1 is ubiquitously expressed and located primarily in focal adhesions [PMID: 1907287, PMID: 11369769]. This entry represents alpha-actinin-1, and also includes alpha-actinin proteins from invertebrates. In contrast to vertebrates, Drosophila sarcomeric and non-muscle alpha-actinins are encoded by a single gene [PMID: 2112549, PMID: 15454267].

GO terms

Biological Process

GO:0051764 actin crosslink formation
GO:0051017 actin filament bundle assembly

Molecular Function

GO:0051015 actin filament binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.