Shisa family (IPR026910)

Short name: Shisa

Overlapping homologous superfamilies


Family relationships



Shisa is a transmembrane, transcription factor-type protein that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface [PMID: 15680320, PMID: 18033675].

The Shisa family founding member, Xenopus Shisa, promotes head development by antagonising Wnt and FGF signaling [PMID: 15680328]. Several vertebrate homologues have been identified with implicated roles in development, cancer and apoptosis [PMID: 16773659, PMID: 18954025, PMID: 12135983]. Distantly related Shisa homologues have also been detected that possess an N-terminal domain with six conserved cysteines. These Shisa-like proteins include SHL2B (protein shisa-like-2B, also known as FAM159B) and SHISAL1 (protein shisa-like-1, also known as KIAA1644) from vertebrates [PMID: 22120523].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.