Domain

Protein ASX-like, PHD domain (IPR026905)

Short name: ASX-like_PHD

Domain relationships

None.

Description

This entry represetnts the PHD domain, a DNA-binding domain, on the additional sex combs (ASX) and additional sex combs-like (AsxL) proteins [PMID: 16412590]. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context [PMID: 19833123].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam