Transcription termination and cleavage factor, C-terminal domain (IPR026896)

Short name: CSTF_C

Overlapping homologous superfamilies

Domain relationships



The C-terminal section of cleavage stimulation and termination factor CstF-64 (CSTF2) and its yeast orthologue Rna15 form a discreet structure that is crucial for mRNA 3'-end processing [PMID: 17116658]. This domain interacts with Pcf11 and possibly PC4, thus linking CSTF2 to transcription, transcriptional termination, and cell growth [PMID: 19887456].

Proteins containing this domain also include Pti1 protein from budding yeast. Pti1 is an essential component of CPF (cleavage and polyadenylation factor) involved in 3' end formation of snoRNA and mRNA [PMID: 12773397].

GO terms

Biological Process

GO:0031124 mRNA 3'-end processing

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.