Toll-like receptor 7 (IPR026880)
Short name: TLR7
Overlapping homologous superfamilies
- Leucine-rich repeat domain superfamily (IPR032675)
Toll-like receptor 7 (TLR7) is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR, which is activated by single-stranded RNA, acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [PMID: 14976261, PMID: 18250417].
GO:0016021 integral component of membrane
- PTHR44312:SF1 (PTHR44312:SF1)