Toll-like receptor 7 (IPR026880)

Short name: TLR7

Overlapping homologous superfamilies

Family relationships



Toll-like receptor 7 (TLR7) is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR, which is activated by single-stranded RNA, acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [PMID: 14976261, PMID: 18250417].

GO terms

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0051607 defense response to virus
GO:0006955 immune response
GO:0034154 toll-like receptor 7 signaling pathway

Molecular Function

GO:0003727 single-stranded RNA binding
GO:0004888 transmembrane signaling receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.