Domain

Myosin-binding domain (IPR026859)

Short name: Myosin-bd

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents a myosin-binding domain found in vezatin and inheritance of peroxisomes protein 2 (Inp2).

Vezatin is a peroxisome transmembrane receptor that is involved in membrane-membrane and cell-cell adhesions. In the movement of peroxisomes, it binds to class V [PMID: 16678774] and class VIIa [PMID: 17379651] myosins to guide the organelle through the microtubules [PMID: 16678774] and allow pathogens to internalise themselves into host cells [PMID: 15090598]. In mouse cells, vezatin is crucial for spermatozoan production [PMID: 17379651]. It interacts with the cadherin-catenin complex bridging it to the C-terminal FERM domain of myosin VIIA [PMID: 11080149].

Inp2 has been identified as the peroxisome-specific receptor for class V myosin, Myo2p [PMID: 16678774].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0017022 myosin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam