Autophagy-related protein 2 (IPR026849)

Short name: ATG2

Overlapping homologous superfamilies


Family relationships


Pexophagy is an autophagic process consisting of the rapid and selective degradation of peroxisomes. Autophagy-related protein 2 (ATG2) is required for glucose-induced micropexophagy and ethanol-induced macropexophagy in yeast [PMID: 11533052, PMID: 11856375]. Homologues of this protein have also been described in mammals and plants. Mammalian ATG2 proteins are thought to function both in autophagosome (a structure that enclose the cytoplasmic materials) formation and regulation of lipid droplet morphology and dispersion [PMID: 22219374]. In plants they have a role in programmed cell death, senescence and disease resistance [PMID: 21645148].

GO terms

Biological Process

GO:0006914 autophagy

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.