E3 SUMO-protein ligase Nse2 (Mms21) (IPR026846)

Short name: Nse2(Mms21)

Overlapping homologous superfamilies


Family relationships



This entry consists of the E3 SUMO-protein ligase Nse2 (also known as Mms21).

Nse2 is an E3 SUMO-protein ligase component of the SMC5-SMC6 complex [PMID: 12966087, PMID: 15601841]. Nse2 acts as an E3 ligase targeting several proteins for sumoylation and is required for efficient DNA repair and maintenance of genome stability [PMID: 22921571, PMID: 16055714, PMID: 15738391, PMID: 21550342]. Nse2 and SMC5 may also be required for sister chromatid cohesion during prometaphase and mitotic progression; this role is apparently independent of SMC6 [PMID: 19502785]. Nse2 is necessary for normal cell cycle progression in Arabidopsis, where Nse2 mutation results in abnormal root development [PMID: 19682286].

GO terms

Biological Process

GO:0000724 double-strand break repair via homologous recombination

Molecular Function

GO:0019789 SUMO transferase activity

Cellular Component

GO:0030915 Smc5-Smc6 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.