Adenomatous polyposis coli (IPR026836)

Short name: APC

Overlapping homologous superfamilies


Family relationships


Adenomatous polyposis coli (APC) is a tumor suppressor protein that induces the degradation of oncogenic beta-catenin and negatively regulates Wnt signalling [PMID: 19619488]. It has roles in regulating cell migration, DNA replication/repair, mitosis and apoptosis [PMID: 17881494, PMID: 22162224]. APC regulates cell-cell adhesion and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (GEF; Asef) [PMID: 10947987, PMID: 21788986]. It acts as a mediator of ERBB2-dependent stabilisation of microtubules at the cell cortex [PMID: 20937854]. It is required for the localisation of MACF1/ACF7 to the cell membrane and this localisation of MACF1/ACF7 is critical for its function in microtubule stabilisation [PMID: 20937854]. APC mutations are particularly prevalent in colorectal cancer [PMID: 1528264].

GO terms

Biological Process

GO:0007050 cell cycle arrest
GO:0016477 cell migration
GO:0006974 cellular response to DNA damage stimulus
GO:0000281 mitotic cytokinesis
GO:0030178 negative regulation of Wnt signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0007026 negative regulation of microtubule depolymerization
GO:0043065 positive regulation of apoptotic process

Molecular Function

GO:0008013 beta-catenin binding

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.