Vacuole morphology and inheritance protein 14 (IPR026825)

Short name: Vac14

Overlapping homologous superfamilies


Family relationships



Vac14 is a component of the PI(3,5)P2 regulatory complex, which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) [PMID: 19037259]. This complex is composed of Atg18, Fig4, Fab1, Vac14 and Vac7 in yeast. In mammals it consists of PIKfyve, FIG4 and VAC14. Fab1/PIKfyve (Fab1 in yeast and PIKfyve in mammals) is a kinase that converts PI(3)P into PI(3,5)P2 by phosphorylation at the 5-position; conversely Fig4 dephosphorylates PI(3,5)P2 back to PI(3)P. Vac14 is a scaffolding adaptor protein whose multimerisation is a prerequisite step for PI(3,5)P2 complex assembly and function [PMID: 23389034].

GO terms

Biological Process

GO:0006661 phosphatidylinositol biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0070772 PAS complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.