Guanine nucleotide exchange factor Ect2 (IPR026817)

Short name: Ect2

Overlapping homologous superfamilies


Family relationships



Epithelial Cell Transforming Sequence 2 (Ect2) is a guanine nucleotide exchange factor (GEF) that catalyses the exchange of GDP for GTP. Like other GEFs, Ect2 serves as molecular switches in diverse signaling pathways, including cell polarity, mitotic spindle assembly, cytokinesis, etc [PMID: 14624449, PMID: 10934474, PMID: 16103226]. Ect2 interacts with several members of the Rho GTPase family including, RhoA, RhoB, RhoC, RhoG, Rac1 and Cdc42 [PMID: 14645260, PMID: 15073184, PMID: 8464478, PMID: 10579713, PMID: 12376551]. Ect2 regulates the formation of the actomyosin contractile ring at mitotic exit through activation of RhoA and functions in metaphase for the process of spindle assembly through activation of Cdc42 [PMID: 19896966]. Ect2 is regulated through a number of mechanisms including phosphorylation, intracellular localization and intra- and inter-molecular interactions [PMID: 19896966].

Ect2 is established as a human oncogene [PMID: 19896966]. It is highly expressed in a variety of human tumors including brain lung, bladder, esophageal, pancreatic and ovarian tumors [PMID: 19008376, PMID: 19118053, PMID: 14645260, PMID: 19118053, PMID: 18842503]. Ect2 is also suggested to play a role in neuronal differentiation and brain development [PMID: 21350944] .

GO terms

Biological Process

GO:0000902 cell morphogenesis
GO:0000910 cytokinesis
GO:0045666 positive regulation of neuron differentiation

Molecular Function

GO:0005096 GTPase activator activity
GO:0005085 guanyl-nucleotide exchange factor activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.