Dedicator of cytokinesis 3 (IPR026800)
Short name: DOCK3
Overlapping homologous superfamilies
- Dedicator of cytokinesis (IPR026791)
- Dedicator of cytokinesis 3 (IPR026800)
DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [PMID: 12432077]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [PMID: 25022758, PMID: 15723800]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [PMID: 12432077].
This entry represents DOCK3. DOCK3 is linked to Alzheimer disease due to its interaction with presenilin proteins and ability to stimulate Tau/MAPT phosphorylation [PMID: 12093789].
- PTHR23317:SF66 (PTHR23317:SF66)