Cornulin (IPR026792)

Short name: Cornulin

Overlapping homologous superfamilies


Family relationships



The cornulin gene is a member of the "fused" gene family. Cornulin is a calcium-binding protein present in the upper layer of squamous epithelia. It might have an important role in epidermal differentiation [PMID: 15854041]. It has been shown to participate in the clonogenicity of squamous esophageal epithelium cell lines, attenuating deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium [PMID: 16640557]. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest [PMID: 15896671].Cornulin is up-regulated after heat shock, ponasterone A and deoxycholic acid [PMID: 11606197, PMID: 15896671, PMID: 16640557].

In humans, a number of genes specifying structural proteins expressed late during epidermal differentiation have been identified and found to be clustered on chromosome 1q21. Therefore, this region is named the epidermal differentiation complex (EDC). The proteins encoded by the EDC genes can be classified into three groups: the precursor proteins of the CE, the S100 family and the "fused" gene family [PMID: 15854042]. In some classification, the "fused gene" family is classified as a subgroup within the S100 gene family [PMID: 9268637].

The "fused" gene family members contain EF hands and internal tandem repeats. It consists of profilaggrin, trichohyalin, repetin, hornerin, the profilaggrin-related protein and cornulin (encoded by c1orf10). They are associated with keratin intermediate filaments and partially cross-linked to the cell envelope (CE) [PMID: 15854042].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.