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Overview
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Pathways & interactions
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Structures
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Cross-references
MLLT11 family (IPR026778)
Short name: MLLT11_fam
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
This entry represents AF1q, encoded by the MLLT11 gene, which is a fusion partner of the MLL (mixed lineage leukemia) gene. The MLL-MLLT11 fusion is linked to the acute leukemias [PMID: 22854283].
At the protein level, AF1q/MLLT11 is highly expressed in thymus and all leukemic cell lines, and is differentially expressed during neuronal differentiation [PMID: 15530661,PMID: 7833468]. It interacts with the Notch signalling pathway to regulate the emergence of human prothymocytes [PMID: 21715312]. It has also been shown that AF1q increases radiation-induced apoptosis through up-regulation of BAD (BCL-2 antagonist of cell death) in human squamous carcinoma via NF-kappaB [PMID: 20596645].
GO terms
Biological Process
GO:0097190 apoptotic signaling pathway
Molecular Function
No terms assigned in this category.
Cellular Component
No terms assigned in this category.
Contributing signatures
- PTHR15404 (PTHR15404)