Family

MLLT11 family (IPR026778)

Short name: MLLT11_fam

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This entry represents AF1q, encoded by the MLLT11 gene, which is a fusion partner of the MLL (mixed lineage leukemia) gene. The MLL-MLLT11 fusion is linked to the acute leukemias [PMID: 22854283].

At the protein level, AF1q/MLLT11 is highly expressed in thymus and all leukemic cell lines, and is differentially expressed during neuronal differentiation [PMID: 15530661,PMID: 7833468]. It interacts with the Notch signalling pathway to regulate the emergence of human prothymocytes [PMID: 21715312]. It has also been shown that AF1q increases radiation-induced apoptosis through up-regulation of BAD (BCL-2 antagonist of cell death) in human squamous carcinoma via NF-kappaB [PMID: 20596645].

GO terms

Biological Process

GO:0097190 apoptotic signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER