InterPro

This entry represents AF1q, encoded by the MLLT11 gene, which is a fusion partner of the MLL (mixed lineage leukemia) gene. The MLL-MLLT11 fusion is linked to the acute leukemias [PMID: 22854283].

At the protein level, AF1q/MLLT11 is highly expressed in thymus and all leukemic cell lines, and is differentially expressed during neuronal differentiation [PMID: 15530661,PMID: 7833468]. It interacts with the Notch signalling pathway to regulate the emergence of human prothymocytes [PMID: 21715312]. It has also been shown that AF1q increases radiation-induced apoptosis through up-regulation of BAD (BCL-2 antagonist of cell death) in human squamous carcinoma via NF-kappaB [PMID: 20596645].