Nucleolar and spindle-associated protein 1 (IPR026756)

Short name: NuSAP

Overlapping homologous superfamilies


Family relationships



Nucleolar and spindle-associated protein 1 (NuSAP) is a microtubule-associated protein with the capacity to bundle and stabilise microtubules [PMID: 12963707]. When overexpressed, it causes profound cytoplasmic microtubule bundling in interphase cells. It localises to the spindle during mitosis. NuSAP depletion by RNA interference results in defect in spindle midzone formation and aberrant anaphase and cytokinesis [PMID: 12963707]. NuSAP may be regulated by phosphorylation during mitosis [PMID: 22101338, PMID: 19786723, PMID: 18669648]. NuSAP is indispensable for mitosis and may play an important role in cancer progression and aggressiveness [PMID: 16170025, PMID: 17960622, PMID: 19915147, PMID: 20388846, PMID: 20053754, PMID: 19266279].

GO terms

Biological Process

GO:0040001 establishment of mitotic spindle localization
GO:0000226 microtubule cytoskeleton organization
GO:0000281 mitotic cytokinesis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005874 microtubule
GO:0005819 spindle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.