Cavin family (IPR026752)

Short name: Cavin_fam

Overlapping homologous superfamilies


Family relationships


This entry represents the cavin family (caveolae-associated proteins; previously known as the PTRF/SDPR family), which includes proteins cavin-1 to 4. They are critical regulators for caveolae dynamics [PMID: 20363285]. Caveolae are invaginations of the plasma membrane involved in many cellular processes, including clathrin-independent endocytosis, cholesterol transport, and signal transduction. Caveolins are the principal components of caveolae membranes. Polymerase I and transcript release factor (PTRF; also known as cavin-1) is essential for formation of caveolae and proper localisation of caveolins [PMID: 19726876].

Cavin-2 (also known as serum deprivation-response protein) may play a role in targeting protein kinase C alpha (PKCalpha) to caveolae [PMID: 9566962]. Cavin-3 (protein kinase C delta-binding protein, also known as SRBC) seems to have an immune potentiation function, especially in the glioma [PMID: 9054438, PMID: 15197346]. Cavin-4 (muscle-related coiled-coil protein) is a muscle-restricted cavin [PMID: 18332105].

The members of the cavin family contain putative leucine zipper-like domains normally involved in protein-protein interactions and PEST domains (proline, glutamic acid, serine and threonine-rich domains), which may play a role in targeting proteins towards proteolytic degradation [PMID: 15242332].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.