Rootletin (IPR026733)

Short name: Rootletin

Overlapping homologous superfamilies


Family relationships



Rootletin is a major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus [PMID: 12427867]. It contributes to centrosome cohesion before mitosis [PMID: 16203858]. Rootletin may function as a physical linker between the pair of centrioles/basal bodies in cells [PMID: 16339073].

GO terms

Biological Process

GO:0007098 centrosome cycle

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0035253 ciliary rootlet

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.