Family

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1/2 (IPR026722)

Short name: NYAP1/NYAP2

Overlapping homologous superfamilies

None.

Family relationships

Description

This entry includes NYAP1 and NYAP2 from neuronal tyrosine-phosphorylated adaptor for the PI 3-kinase (NYAP) family (consists of NYAP1, NYAP2, NAP3/Myosin16). NYAPs activate PI3K in PI3K pathway, which is a fundamental pathway for various cellular events in neurons. They also interact with components of the WAVE1 complex, which mediates actin cytoskeleton remodeling through Arp2/3 complex. It was suggested that NYAPs connect PI3K activation to WAVE1 signalling in neurons [PMID: 21946561].

GO terms

Biological Process

GO:0048812 neuron projection morphogenesis
GO:0014065 phosphatidylinositol 3-kinase signaling

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER