Family

Choline/Ethanolamine kinase (IPR026712)

Short name: Cho/Etha_kinase

Family relationships

None.

Description

The choline/ethanolamine kinase family includes choline kinase (EC:2.7.1.32) and ethanolamine kinase (EC:2.7.1.82).

Ethanolamine and choline are major membrane phospholipids, in the form of glycerophosphoethanolamine and glycerophosphocholine. Ethanolamine is also a component of the glycosylphosphatidylinositol (GPI) anchor, which is necessary for cell-surface protein attachment [PMID: 18489261]. The de novo synthesis of these phospholipids begins with the creation of phosphoethanolamine and phosphocholine by ethanolamine and choline kinases in the first step of the CDP-ethanolamine pathway [PMID: 16861741, PMID: 9506987]. There are two putative choline/ethanolamine kinases (C/EKs) in the Trypanosoma brucei genome.

Besides catalysing the phosphorylation of choline to phosphorylcholine in the presence of ATP, choline kinase also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline. It may contribute to tumor cell growth in humans [PMID: 22429312].

Ethanolamine kinase has no choline kinase activity [PMID: 18489261] and its activity is inhibited by ADP [PMID: 9506987]. Inositol supplementation represses ethanolamine kinase, decreasing the incorporation of ethanolamine into the CDP-ethanolamine pathway and into phosphatidylethanolamine and phosphatidylcholine [PMID: 15201274].

GO terms

Biological Process

GO:0046474 glycerophospholipid biosynthetic process

Molecular Function

GO:0016301 kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER