Family

WASP homologue-associated protein with actin, membranes and microtubules (IPR026688)

Short name: WHAMM

Family relationships

None.

Description

WASP homologue-associated protein with actin, membranes and microtubules (WHAMM) contains three domains, an N-terminal domain that mediates Golgi membrane association, a coiled-coil region that binds microtubules, and one or two WH2 domains that stimulate Arp2/3-mediated actin polymerisation. It acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerisation both at the Golgi apparatus and along tubular membranes. It is involved as a regulator of Golgi positioning and morphology. It also participates in vesicle transport between the reticulum endoplasmic and the Golgi complex [PMID: 18614018].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER