Family

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein (IPR026674)

Short name: ALS2CR12

Family relationships

None.

Description

Juvenile amyotrophic lateral sclerosis (ALS) is a form of chronic motor neuron disease characterised by combined upper and lower motor neuron symptoms. Amyotrophic lateral sclerosis 2 (ALS2) is an autosomal recessive form of juvenile ALS and has been mapped to human chromosome 2q33 [PMID: 11586298]. Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein (ALS2CR12) is a putative GTPase regulator and its mutation is linked to the familial amyotrophic lateral sclerosis 2 [PMID: 11586298].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER