Pathways & interactions
Short name: PPP1R18/Tprn
Overlapping homologous superfamilies
- Phostensin/Taperin (IPR026671)
- Taperin (IPR033359)
This entry includes Phostensin and Taperin.
Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends [PMID: 19622346]. Phostensin interacts with Protein phosphatase 1 (PP1). It is likely that phostensin targets PP1 to the F-actin cytoskeleton [PMID: 17374523].
Taperin (TPRN) is also a PP1 binding protein that is ancestrally related to phostensin. It localised prominently at the taper regions of hair cell stereocilia and has a role in sound perception [PMID: 20170899]. Defects in human TPRN are the cause of deafness autosomal recessive type 79 (DFNB79). DFNB79 is characterised by progressive hearing loss leading to profound deafness. There are no symptoms of vestibular dysfunction [PMID: 20170899, PMID: 15302935].
- PTHR21685 (PTHR21685)