Pathways & interactions
Bcl-2-associated transcription factor 1 (IPR026668)
Short name: Bcl-2_assoc_TF1
Overlapping homologous superfamilies
- THRAP3/BCLAF1 family (IPR029199)
- Bcl-2-associated transcription factor 1 (IPR026668)
Bcl-2-associated transcription factor 1 (Btf) is a death-promoting transcriptional repressor that has been shown to interact with Bcl-2 and Bcl-XL [PMID: 10330179]. It is involved in the proapoptotic C16-ceramide-dependent pathway [PMID: 19705920]. Btf's regulation by PKC-delta also has a critical role in determining cell fate with DNA damage [PMID: 17938203].
- PTHR15268:SF4 (PTHR15268:SF4)