NADH-quinone oxidoreductase subunit CD (IPR026662)

Short name: NDH-1_subunit_CD

Overlapping homologous superfamilies

Family relationships


NADH dehydrogenase I (NDH-1) shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centres, to quinones in the respiratory chain. It is composed of a number of different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.

This entry represents the NuoC-NuoD fusion found in Aquificae, Bacteroidetes, Delta-and Epsilonproteobacteria. The NuoCD fusion protein found in the Alpha-, Beta- and Gammaproteobacteria is different enough that it seems to be another subfamily (see IPR023062). In many bacteria there are both the individual and fused versions.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0050136 NADH dehydrogenase (quinone) activity

Cellular Component

GO:0030964 NADH dehydrogenase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.