Proline/serine-rich coiled-coil protein 1/G2 and S phase-expressed protein 1 (IPR026657)

Short name: DDA3/GTSE-1

Overlapping homologous superfamilies


Family relationships


This is a family of phosphoproteins which includes proline/serine-rich coiled-coil protein 1 (PSRC1, also known as DDA3) and G2 and S phase-expressed protein 1 (GTSE1).

DDA3 is a microtubule-destabilising protein that controls spindle dynamics and mitotic progression by regulating microtubule depolymerases, such as Kif2a and MCAK [PMID: 18411309, PMID: 21426902]. Deletion of DDA3 causes spindle hyper-stabilisation, inter-kinectochore tension loss, chromosome congression defects. This leads to unaligned chromosomes at metaphase and the accumulation of CENP-E (a plus end-motor protein) at kinectochore in these chromosomes [PMID: 21426902]. It has also been suggested that DDA3 may participate in p53/TP53-regulated growth suppression [PMID: 10618717].

GTSE1 may be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis [PMID: 20577264]. When overexpressed, GTSE1 delays G2/M phase progression [PMID: 9724637].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.