N-acetyltransferase ESCO1 (IPR026656)

Short name: AcTrfase_ESCO1

Overlapping homologous superfamilies


Family relationships



N-acetyltransferase ESCO1 (also known as ECO1/EFO1) and ESCO2 are required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. They act by mediating the acetylation of cohesin component SMC3 [PMID: 19907496]. They feature a conserved C-terminal domain consisting of a H2C2 zinc finger motif (IPR028005) and an acetyltransferase domain (IPR028009), while the diverse N-terminal domain is involved in chromosome binding and could target these proteins to different chromosome structures [PMID: 15958495].

This entry represents ESCO1.

GO terms

Biological Process

GO:0034421 post-translational protein acetylation
GO:0006275 regulation of DNA replication
GO:0007062 sister chromatid cohesion

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000785 chromatin

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.