Protein TESPA1 (IPR026647)

Short name: TESPA1

Overlapping homologous superfamilies


Family relationships



TESPA1 (Thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. It plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes [PMID: 22561606].

GO terms

Biological Process

GO:0010387 COP9 signalosome assembly
GO:0050862 positive regulation of T cell receptor signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.