Nuclear receptor coactivator 6 (IPR026638)

Short name: NCOA6

Overlapping homologous superfamilies


Family relationships



Nuclear receptor coactivator 6 (NCOA6, also known as ASC-2, TRBP and RAP250) is a general coactivator [PMID: 10681503, PMID: 10823961]. It is involved in the coactivation of different nuclear receptors, such as steroid receptors (GR and ERs), retinoid receptors (RARs and RXRs), thyroid hormone receptors (TRs), vitamin D3 receptor (VDR) and prostanoid receptors (PPARs) [PMID: 10567404]. NCOA6 possesses an LXXLL sequence motif, which mediates its interaction with nuclear receptors [PMID: 10823961, PMID: 11773444]. Altered expression of NCOA6 may contribute to the development of certain cancers [PMID: 10567404].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003713 transcription coactivator activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.