Family

Serine/threonine-protein kinase MRCK alpha (IPR026611)

Short name: Ser/Thr_kinase_MRCK_alpha

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Serine/threonine-protein kinase MRCK (myotonic dystrophy kinase-related CDC42-binding kinase) is an serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in actin-myosin regulation and activities including cell adhesion, motility and invasion [PMID: 18854160, PMID: 21457715]. Three isoforms have been described in mammals: alpha, beta and gamma [PMID: 15194684, PMID: 24553779].

This entry represent the serine/threonine-protein kinase MRCK alpha. It also includes the Drosophila homologue Genghis khan (Gek) [PMID: 9371783, PMID: 22007130].

GO terms

Biological Process

GO:0030036 actin cytoskeleton organization

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER