Pathways & interactions
DMRT/protein doublesex/protein male abnormal 3 (IPR026607)
Short name: DMRT/dsx/mab-3
Overlapping homologous superfamilies
- DM DNA-binding domain superfamily (IPR036407)
- DMRT/protein doublesex/protein male abnormal 3 (IPR026607)
This family consists of DMRT (doublesex- and mab-3-related transcription factor) proteins, protein doublesex (dsx) and protein male abnormal 3 (mab-3).
Mab-3 promotes male-specific development of two tissues. In the peripheral nervous system, it directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, It causes repression of vitellogenin gene transcription. It binds the DNA motif 5'-[CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer [PMID: 9490411].
DsX controls somatic sexual differentiation. It binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. It is involved in regulation of male-specific expression of takeout in brain-associated fat body [PMID: 12435630].
The DMRT gene family encodes putative transcription factors related to the sexual regulators doublesex (Drosophila melanogaster) and mab-3 (Caenorhabditis elegans). Its members are involved in sex determination/differentiation [PMID: 15008421].
- PTHR12322 (PTHR12322)