Secreted frizzled-related protein 3 (IPR026556)

Short name: SFRP3

Family relationships


Secreted frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts [PMID: 9096311]. They have a role in regulating cell growth and differentiation in specific cell types.

SFRP3 (also known as FRZB) regulates chondrocyte maturation and long bone development [PMID: 12413904]. It is an antagonist of Wnt8 signalling [PMID: 9118219].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.