Smoothened (IPR026544)

Short name: SMO

Overlapping homologous superfamilies


Family relationships


This entry represents smoothened (SMO) and its homologues, which are related to the frizzled protein family. Smoothened is a G protein-coupled receptor that is involved in the hedgehog signalling pathway. Smoothened probably associates with the patched protein to transduce the hedgehog's proteins signal [PMID: 19592253]. Mutated smoothened can function as an oncogene [PMID: 9422511].

GO terms

Biological Process

GO:0007224 smoothened signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.