Dishevelled Dsh (IPR026542)

Short name: Dsh

Overlapping homologous superfamilies


Family relationships


Dishevelled (Dsh) proteins possess three conserved domains: an amino-terminal DIX domain, a central PDZ and a carboxyl-terminal DEP domain. They acts downstream of Fz receptors in the Wnt signalling pathway, which controls a variety of developmental and homeostatic events [PMID: 15353129].

This entry represents Dsh from Drosophila and related proteins from invertebrates. It is required to establish coherent arrays of polarised cells and segments in embryos [PMID: 7744250]. It interacts with naked cuticle (Nkd), an evolutionarily conserved inducible antagonist of Wnt/beta-catenin signalling that is crucial for segmentation in Drosophila [PMID: 16849595].

GO terms

Biological Process

GO:0016055 Wnt signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.