Antiviral radical SAM protein viperin (IPR026372)

Short name: Viperin

Overlapping homologous superfamilies

Family relationships


Viperin (Virus Inhibitory Protein, ER-associated, Iterferon-inducible) is a radical SAM enzyme found in human and other vertebrates. It is both induced by interferon and demonstrably active in blocking replication by several types of virus, apparently by modifying lipid chemistries in lipid droplets and membrane rafts [PMID: 10698968, PMID: 9971762, PMID: 15350746, PMID: 17686841].

Human Viperin is involved in antiviral defense. It may impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. It acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. It plays a major role in the cell antiviral state induced by type I and type II interferon. It displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus [PMID: 11752458, PMID: 16108059, PMID: 16982913, PMID: 17686841, PMID: 18005719].

GO terms

Biological Process

GO:0051607 defense response to virus

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.