Family

Transmembrane protein 132 (IPR026307)

Short name: TMEM132

Family relationships

None.

Description

This family consists of TMEM132A, TMEM132B, TMEM132C, TMEM132D, TMEM132E. They all have transmembrane domains.

TMEM132A may play a role in embryonic and postnatal development of the brain. It increased resistance to cell death induced by serum starvation in cultured cells. It regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation [PMID: 12514190, PMID: 16806201].

TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation [PMID: 12966072, PMID: 16806201]. Additionally, as it may be most strongly expressed in neurons and it colocalises with actin filaments, TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour [PMID: 22948381].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER