FMRFamide-related peptide/Growth hormone-releasing peptide (IPR026297)

Short name: FMRFamide-related/fGRP

Overlapping homologous superfamilies


Family relationships



This family includes both FMRFamide-related peptides and growth hormone-releasing peptides.

FMRFamide-related peptides are neurotransmitters, hormone-like substances and tumor suppressor peptides [PMID: 21524675]. Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide NPVF blocks morphine-induced analgesia. FMRFamide-related peptides may act in concert with kisspeptin, through opposing affects, to regulate the activity of gonadotropin-releasing hormone (GnRH) neurons across the seasons, leading to an annual change in fertility and the cyclical seasonal transition from non-breeding to breeding season [PMID: 18617612, PMID: 18617613, PMID: 9808777].

The primary role of growth hormone-releasing peptide (fGRP) is to release GH from the pituitary [PMID: 11796493].

GO terms

Biological Process

GO:0007218 neuropeptide signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.