Submaxillary gland androgen-regulated protein like (IPR026288)

Short name: SMR-like

Overlapping homologous superfamilies


Family relationships



This entry includes submaxillary gland androgen-regulated proteins SMR1,SMR2, SMR3. This entry also includes opiorphin prepropeptide from humans.

SMR1 gene gives rise to four related peptides: SMR1-undecapeptide, SMR1-hexapeptide, SMR1-pentapeptide [PMID: 8112327] and submandibular gland peptide T [PMID: 9321881].

Submandibular gland peptide T is able to down-regulate cardiovascular depression induced by septic or anaphylactic shock [PMID: 9321881].

SMR1-pentapeptide (also called Sialorphin) may be involved in the modulation of mineral balance between at least four systems: kidney, bone, tooth and circulation. It is synthesized predominantly in the submandibular gland and prostate of adult rats in response to androgen steroids and is released locally and systemically in response to stress. It is an endogenous inhibitor of neprilysin. It inhibits the breakdown of Met-enkephalin and substance P in isolated tissue from the dorsal zone of the rat spinal cord. It has an analgesic effect when administered to rats by intravenous injection [PMID: 9321881, PMID: 9362294, PMID: 12835417].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.