Tissue plasminogen activator (IPR026280)

Short name: Tissue_plasm_act

Overlapping homologous superfamilies


Family relationships


Tissue-type plasminogen activator is a serine peptidase belonging to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A.

The fibrinolytic system is the mechanism by which blood clots are dissolved via the plasmin-mediated degradation of fibrin into soluble end products. The system is activated by urokinase-type plasminogen activator (uPA; EC: or by tissue-type plasminogen activator (tPA; EC:; this family), which are enzymes that convert the inactive proenzyme plasminogen to the active protease plasmin [PMID: 11460480].

tPA is mainly involved in the activation of circulating plasminogen, while uPA activates cell-bound plasminogen after binding to a specific uPA receptor (uPAR).

Following the signal sequence and propeptide regions, tPA typically contains a fibronectin type I (FN1) domain, an EGF-type domain, two kringle domains and a trypsin domain. However, there are members missing FN1 or EGF or one of the kringles.

This entry also includes salivary plaminogen activators from the vampire bat (Desmodus rotundus).

GO terms

Biological Process

GO:0031639 plasminogen activation
GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.