Sigma-E factor negative regulatory protein RseA (IPR026279)

Short name: RseA

Overlapping homologous superfamilies


Family relationships



Sigma-E is important for the induction of proteins involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and preventing transcription from heat-shock promoters [PMID: 9159523]. Activation of the the sigma(E)-dependent extracytoplasmic stress response requires the regulated proteolysis of RseA [PMID: 12183369], leading to an increase in the free pool of sigma(E) [PMID: 10500101].

GO terms

Biological Process

GO:0006950 response to stress

Molecular Function

GO:0016989 sigma factor antagonist activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.