PRAME family (IPR026271)

Short name: PRAME_family

Overlapping homologous superfamilies

Family relationships



Preferentially expressed antigen of melanoma (PRAME) was first isolated as a human melanoma antigen by cDNA expression cloning using melanoma-reactive cytotoxic Tcells (CTL). PRAME is a tumor associated antigen (TAA) of particular interest since it is widely expressed by lymphoid and myeloid malignancies and solid tumors, including melanomas, sarcomas, head and neck cancers, small-cell lung carcinomas and renal cell cancers. In normal tissues, PRAME expression has been reported in testis and low levels are found in endometrium, ovaries and adrenals [PMID: 9047241, PMID: 17108098, PMID: 9753074, PMID: 16044453]. However, the PRAME gene is also expressed, although at a lower intensity, in CD34+ stem cells from healthy donors, which might constitute a problem for its application as a target in tumor immunotherapy [PMID: 11943337]. Epigenetic events represent the main mechanism regulating the expression of PRAME including DNA methylation of several promoter regions [PMID: 18282509, PMID: 17382387].

Members of the PRAME gene family encode leucine-rich repeat (LRR) proteins functioning as transcription regulators in cancer cells, and are thought to possess roles in spermatogenesis and oogenesis [PMID: 23565261, PMID: 16159394].

GO terms

Biological Process

GO:0043066 negative regulation of apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.