L-arabinose-binding periplasmic protein (IPR026266)

Short name: AraF

Overlapping homologous superfamilies

Family relationships



Periplasmic L-arabinose-binding protein (ABP) is involved in the high-affinity L-arabinose membrane transport system. It binds with high affinity to arabinose, but can also bind D-galactose (at approximately 2-fold lower affinity) and D-fucose (at approximately 40-fold lower affinity) [PMID: 7031057, PMID: 2204627].

The periplasmic ABP consists of two alpha/beta globular domains connected by a three-stranded hinge, a Venus flytrap-like domain, which undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, ABP is homologous to the ligand-binding domain of eukaryotic receptors such as metabotropic glutamate receptor (mGluR) and DNA-binding transcriptional repressors such as LacI and GalR [PMID: 11741199].

GO terms

Biological Process

GO:0042882 L-arabinose transmembrane transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.