Signal recognition particle subunit SRP68 (IPR026258)

Short name: SRP68

Overlapping homologous superfamilies


Family relationships



The signal recognition particle (SRP) is a large ribonucleoprotein complex that targets secretory and membrane proteins to the endoplasmic reticulum membrane [PMID: 17254600]. The mammalian SRP contains a 303-nucleotide SRP RNA and six proteins, named SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72. Among them, the two largest, SRP68 and SRP72, form a stable SRP68/72 heterodimer of unknown structure, which is required for sorting secretory proteins [PMID: 19693936]. SRP68 binds to SRP RNA directly, while SRP72 binds the SRP RNA largely via non-specific electrostatic interaction. The binding of SRP72 with SRP RNA enhances the affinity of SRP68 for the RNA.

GO terms

Biological Process

GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Molecular Function

GO:0008312 7S RNA binding
GO:0030942 endoplasmic reticulum signal peptide binding
GO:0005047 signal recognition particle binding

Cellular Component

GO:0005786 signal recognition particle, endoplasmic reticulum targeting

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.