Aquaporin 10 (IPR026252)

Short name: Aquaporin_10

Overlapping homologous superfamilies

Family relationships


Aquaporins form water-specific channels that provide the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Aquaporin amino acid sequences contain two tandem repeats, each containing three transmembrane (TM) domains and a pore-forming loop, with the signature motif Asn-Pro-Ala (NPA).

Aquaporin-10 (AQP10) forms a water channel required to promote glycerol/urea permeability and water transport across cell membranes [PMID: 12084581]. AQP10 may contribute to water transport in the upper portion of small intestine. The family is expressed exclusively in duodenum and jejunum. The highest expression in absorptive epithelial cells is at the tips of villi within the jejunum [PMID: 11573934]. It was initially reported that AQP10 had poor water and no glycerol/urea permeabilities [PMID: 11573934]. However, this has been disputed, and may be due to identification of an incompletely spliced form, which has no conserved sixth TM domain [PMID: 12084581].

GO terms

Biological Process

GO:0006833 water transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.