GATS-like family (IPR026249)

Short name: GATS-like

Family relationships


The GATS-like proteins (also known as stromal antigen 3 opposite strand, or opposite strand transcription unit to STAG3) constitute a gene family, well-conserved in eukaryotes (including human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish) [PMID: 16305752, PMID: 19468303]. To date, in addition to the putative GATS protein, three subtypes, designated GATL1, GATL2 and GATL3 have been identified in humans.

GATL3 and GATL2 has been renamed CASTOR1 and CASTOR2 respectively. CASTOR1 can form homodimers and bind arginine. It can also form heterodimers with GATOR2. The arginine binding of CASTOR1 disrupts the CASTOR1-GATOR2 interaction, and this triggers downstream activation of mTORC1 [PMID: 27487210]. Therefore, CASTOR1 functions as an intracellular arginine sensor for the mTORC1 Pathway [PMID: 26972053, PMID: 27487210]. Interestingly, CASTOR1 shares substantial structural homology with the lysine-binding regulatory domain of prokaryotic aspartate kinases [PMID: 27487210].

The function of GATL1 is not clear.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.