Family

CASTOR family (IPR026249)

Short name: CASTOR_fam

Overlapping homologous superfamilies

None.

Family relationships

Description

CASTOR family members are well-conserved in eukaryotes (including human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish) [PMID: 16305752, PMID: 19468303]. Three subtypes, designated CASTOR1, CASTOR2 and CASTOR3, have been identified in humans.

CASTOR1 can form homodimers and bind arginine. It can also form heterodimers with CASTOR2 [PMID: 26972053]. The arginine binding of CASTOR1 disrupts the CASTOR1-GATOR2 interaction, and this triggers downstream activation of mTORC1 [PMID: 27487210]. Therefore, CASTOR1 functions as an intracellular arginine sensor for the mTORC1 Pathway [PMID: 26972053, PMID: 27487210]. Interestingly, CASTOR1 shares substantial structural homology with the lysine-binding regulatory domain of prokaryotic aspartate kinases [PMID: 27487210].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS