Inheritance of peroxisomes protein 2 (IPR026235)

Short name: INP2

Overlapping homologous superfamilies


Family relationships



Faithful inheritance of organelles by daughter cells is essential to retain the benefits afforded to eukaryotic cells by compartmentalisation of biochemical functions. In Saccharomyces cerevisiae, the class V myosin, Myo2p, is involved in transporting different organelles, including the peroxisome, along actin cables to the bud [PMID: 16678774].

Inp2p has been identified as the peroxisome-specific receptor for Myo2p. Cells lacking Inp2p fail to partition peroxisomes to the bud, although they are unaffected in the inheritance of other organelles. Inp2p is a peroxisomal membrane protein, interacting directly with the globular tail of Myo2p. Cells that over-produce Inp2p often transfer their entire populations of peroxisomes to buds. Levels of Inp2p oscillate with the cell cycle. Organelle-specific receptors like Inp2p illustrate how a single motor can move different organelles in distinct and specific patterns. Inp2p is the first peroxisomal protein implicated in the vectorial movement of peroxisomes [PMID: 16678774].

GO terms

Biological Process

GO:0045033 peroxisome inheritance

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005779 integral component of peroxisomal membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.