Inheritance of peroxisomes protein 2 (IPR026235)

Short name: INP2

Family relationships



Faithful inheritance of organelles by daughter cells is essential to retain the benefits afforded to eukaryotic cells by compartmentalisation of biochemical functions. In Saccharomyces cerevisiae, the class V myosin, Myo2p, is involved in transporting different organelles, including the peroxisome, along actin cables to the bud [PMID: 16678774].

Inp2p has been identified as the peroxisome-specific receptor for Myo2p. Cells lacking Inp2p fail to partition peroxisomes to the bud, although they are unaffected in the inheritance of other organelles. Inp2p is a peroxisomal membrane protein, interacting directly with the globular tail of Myo2p. Cells that over-produce Inp2p often transfer their entire populations of peroxisomes to buds. Levels of Inp2p oscillate with the cell cycle. Organelle-specific receptors like Inp2p illustrate how a single motor can move different organelles in distinct and specific patterns. Inp2p is the first peroxisomal protein implicated in the vectorial movement of peroxisomes [PMID: 16678774].

GO terms

Biological Process

GO:0045033 peroxisome inheritance

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005779 integral component of peroxisomal membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.