Vesicular, overexpressed in cancer, prosurvival protein 1 (IPR026229)

Short name: VOPP1

Overlapping homologous superfamilies


Family relationships



Ectopic expression of vesicular, over-expressed in cancer, pro-survival protein 1, VOPP1 (formerly known as EGFR-co-amplified and over- expressed protein (ECop)) increases NF-kappaB transcriptional activity [PMID: 15735698]. This is achieved by promoting nuclear translocation and DNA binding of NF-kappaB. Ecop-induced NF-kappaB activation confers cellular resistance to apoptotic challenge [PMID: 15735698]. It is believed that ECop is a key regulator of NF-kappaB signalling, and that high-level, amplification-mediated ECop expression, such as occurs in tumours with amplified EGFR, may contribute to resistance to apoptosis [PMID: 15735698].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030659 cytoplasmic vesicle membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.