Jagged/Serrate protein (IPR026219)
Short name: Jagged/Serrate
- Jagged/Serrate protein (IPR026219)
- Protein jagged-2 (IPR033108)
The Notch signalling pathway is a conserved intercellular signalling mechanism that is essential for proper embryonic development in numerous metazoan organisms [PMID: 10221902]. Members of the Notch gene family encode transmembrane (TM) receptors that are critical for various cell-fate decisions. Multiple ligands that activate Notch and related receptors have been identified, including the Delta and Serrate proteins in Drosophila, and Jagged, the vertebrate orthologue of Serrate [PMID: 9315665].
Members of the Jagged/Serrate group are single-pass TM proteins. They possess a large extracellular region that contains a highly conserved disulphide-rich Delta/Serrate/LAG-2 (DSL) domain, and a variable number of EGF repeats. The cytoplasmic tail region is relatively short (100-150 amino acids) and, following proteolytic cleavage, may translocate to the nucleus to mediate nuclear signalling events [PMID: 12551931].
Defects in Jagged have been shown to result in Alagille syndrome, an autosomal dominant disorder that results in a paucity of intrahepatic bile ducts [PMID: 16575836].
This entry represents the Jagged/Serrate protein family.
- PR02059 (JAGGEDFAMILY)