DNA-directed RNA polymerase II subunit GRINL1 (IPR026213)

Short name: GRINL1

Overlapping homologous superfamilies


Family relationships



GRINL1 family consists of GRINL1A and GRINL1B. GRINL1 appears to be a stable component of the Pol II (G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. GRINL1 may play a role in the Mediator complex-dependent regulation of transcription activation. It acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II [PMID: 16769904].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016591 DNA-directed RNA polymerase II, holoenzyme

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.